Prograf: Compound Profile
Prograf 1mg Astellas Pharma is a pharmaceutical-grade immunosuppressive agent containing tacrolimus, a potent calcineurin inhibitor derived from Streptomyces tsukubaensis. This macrolide lactone compound demonstrates selective immunomodulatory properties through its interaction with FK binding protein 12 (FKBP12), forming complexes that inhibit calcineurin phosphatase activity. Researchers at Stroid UK Shop can investigate this compound’s molecular mechanisms in controlled laboratory environments. Tacrolimus represents a critical tool for studying T-cell activation pathways, cytokine production modulation, and immunological tolerance mechanisms in various experimental models.
Laboratory Applications
Research scientists examine tacrolimus in immunology laboratories to investigate its effects on lymphocyte proliferation, interleukin-2 gene transcription, and nuclear factor activation pathways. Studies focus on the compound’s ability to bind with cyclophilin proteins and modulate downstream signaling cascades. Comparative research with other immunosuppressive compounds helps elucidate unique mechanistic properties. Laboratory investigations also explore tacrolimus pharmacokinetics, metabolism through hepatic cytochrome P450 3A4 systems, and tissue distribution patterns. Researchers analyze concentration-dependent effects on cell viability, protein synthesis inhibition, and apoptotic pathway activation in various cell culture systems. Advanced studies incorporate tacrolimus into models examining autoimmune responses, transplantation tolerance, and inflammatory cascade modulation. The compound’s narrow therapeutic index makes it valuable for studying dose-response relationships in experimental settings. Scientists also investigate drug-drug interactions with CYP3A4 inhibitors and inducers, providing insights into metabolic pathway influences. Research applications extend to studying the compound’s effects on calcium-dependent signaling, T-helper cell differentiation, and regulatory T-cell function. Comparative studies with selective androgen receptor modulators and research peptides help establish immunomodulatory specificity profiles.
Product Specifications
| Parameter | Specification |
|---|---|
| Active Ingredient | Tacrolimus |
| Concentration | 1mg per capsule |
| Manufacturer | Astellas Pharma |
| CAS Number | 104987-11-3 |
| Molecular Formula | C₄₄H₆₉NO₁₂ |
| Molecular Weight | 804.0 g/mol |
| Storage Conditions | Room temperature, dry environment |
| Research Grade | Pharmaceutical standard |
Research Compliance
Prograf 1mg Astellas Pharma is supplied exclusively for in-vitro research purposes and laboratory investigations. This product is not intended for human consumption, therapeutic use, or diagnostic applications. Researchers must maintain appropriate laboratory safety protocols and disposal procedures when handling this immunosuppressive compound. All studies should comply with institutional research ethics guidelines and regulatory requirements for controlled substance research.
