Pharmaceutical Research Overview
Tuloplast 2mg is a pharmaceutical-grade tolvaptan formulation manufactured by Zuventus Healthcare Ltd. Tolvaptan is a benzazepine derivative classified as a selective vasopressin V2 receptor antagonist, originally developed for clinical investigation of hyponatremic conditions and autosomal dominant polycystic kidney disease. This compound represents a valuable research tool for laboratories examining aquaretic mechanisms, renal electrolyte handling, and vasopressin signaling pathways. Research scientists at Stroid UK Shop utilize tolvaptan formulations to investigate the complex interactions between antidiuretic hormone receptors and fluid balance regulation in controlled laboratory environments.
Laboratory Research Applications
Researchers examine tolvaptan’s mechanism of action through its selective antagonism of vasopressin V2 receptors located primarily in renal collecting duct cells. In vitro studies investigate how this antagonism prevents the insertion of aquaporin-2 water channels, effectively blocking water reabsorption and promoting aquaresis without significant electrolyte loss. Laboratory protocols evaluate tolvaptan’s pharmacokinetic properties, including its extensive hepatic metabolism via CYP3A4 enzymes and its approximately 12-hour elimination half-life in research models. Scientists studying specialized pharmaceutical compounds analyze concentration-dependent effects on urine osmolality and free water clearance mechanisms. Advanced research applications include examining potential interactions with other vasopressin receptor subtypes and investigating cellular signaling cascades downstream of V2 receptor blockade. Comparative studies evaluate tolvaptan against other diuretic mechanisms, particularly examining its unique aquaretic properties versus traditional natriuretic effects observed with conventional diuretics available through selective research modulators.
Technical Specifications
| Active Compound | Tolvaptan |
|---|---|
| Strength | 2mg per tablet |
| Manufacturer | Zuventus Healthcare Ltd |
| CAS Number | 150683-30-0 |
| Molecular Formula | C₂₆H₂₅ClN₂O₃ |
| Molecular Weight | 448.94 g/mol |
| Classification | Selective Vasopressin V2 Receptor Antagonist |
| Storage Temperature | Room temperature, dry environment |
Quality assurance protocols ensure consistent pharmaceutical standards for research applications requiring reliable tolvaptan reference materials. Each batch undergoes comprehensive analytical testing to verify identity, purity, and stability parameters essential for reproducible laboratory investigations of vasopressin receptor pharmacology and renal physiology studies conducted alongside other specialized research compounds.
Research Compliance Standards
This product is manufactured exclusively for in-vitro research purposes and laboratory investigations. Tuloplast 2mg tolvaptan is not intended for human consumption, clinical use, or any therapeutic applications. Researchers must maintain appropriate laboratory safety protocols and disposal procedures when handling this pharmaceutical-grade research material in accordance with institutional guidelines.
