Orlistat Research Compound Overview
Orlistat is a saturated derivative of lipstatin, functioning as a potent and selective inhibitor of pancreatic and gastric lipases. This pharmaceutical-grade compound operates through covalent binding to the active serine residue of lipase enzymes, preventing the hydrolysis of dietary triglycerides. Research laboratories investigating lipid metabolism, enzymatic inhibition mechanisms, and digestive biochemistry pathways utilise orlistat as a reference standard for in-vitro studies. The compound demonstrates irreversible inhibition kinetics with specific selectivity for lipase enzymes over other digestive proteases.
Laboratory Research Applications
Scientific investigations examine orlistat’s molecular interactions with pancreatic lipase crystalline structures and its effects on triglyceride hydrolysis in controlled environments. Researchers at Stroid UK Shop analyse its binding affinity to lipase active sites and subsequent conformational changes in enzyme structure. Studies focus on dose-response relationships in enzymatic inhibition assays and comparative analysis with other lipase inhibitors. The compound serves as a valuable tool for investigating metabolic modulation pathways and lipid processing mechanisms. Research extends to examining orlistat’s stability under various pH conditions and temperature ranges typical of digestive environments. Advanced proteomics laboratories investigate its selectivity profile against related enzyme families and potential off-target interactions. Studies also evaluate its solubility characteristics and formulation stability for pharmaceutical research applications.
Research Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | Orlistat (Tetrahydrolipstatin) |
| CAS Number | 96829-58-2 |
| Molecular Formula | C₂₉H₅₃NO₅ |
| Molecular Weight | 495.73 g/mol |
| Purity | Pharmaceutical grade |
| Storage Conditions | Room temperature, dry environment |
| Research Focus | Lipase inhibition studies |
Laboratories studying enzyme kinetics analyse orlistat’s mechanism through competitive binding assays and structural biology approaches. Research applications include investigation of selective receptor modulators and comparison with peptide-based inhibitors in metabolic research protocols.
Research Safety and Compliance
Orlistat is supplied exclusively for in-vitro research applications and laboratory analysis only. This compound is not intended for human consumption, therapeutic use, or any clinical applications. Researchers must follow appropriate laboratory safety protocols when handling this material and ensure compliance with institutional research guidelines. All studies should be conducted within approved research facilities with proper ventilation and safety equipment. This product is restricted to qualified research institutions and licensed laboratories for legitimate scientific investigation purposes only.
