Research Applications for Sildenafil
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor extensively studied for its vasodilation properties in cardiovascular research. Originally developed for pulmonary arterial hypertension research, this compound has become a cornerstone reference standard for investigating cyclic GMP pathways and endothelial function in laboratory settings. The 50mg tablet formulation from HEMI PHARMA provides researchers with consistent dosing for experimental protocols examining vascular biology and nitric oxide-dependent signalling mechanisms. Research teams investigating Stroid UK Shop particularly value sildenafil’s well-characterised mechanism of action and extensive pharmacological profile documented across decades of clinical investigation.
Pharmacological Research Context
Laboratory studies examine sildenafil’s selective inhibition of phosphodiesterase type 5, which leads to increased cyclic guanosine monophosphate levels in smooth muscle tissue. This mechanism makes it valuable for researchers studying vascular smooth muscle relaxation, pulmonary circulation dynamics, and nitric oxide pathway modulation. The compound demonstrates good oral bioavailability in research models, with peak plasma concentrations typically achieved within 30-120 minutes post-administration. Researchers working with erectile dysfunction compounds often compare sildenafil’s activity profile against other PDE5 inhibitors to understand selectivity differences and duration of action variations in experimental protocols.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate |
| CAS Number | 139755-83-2 |
| Molecular Formula | C₂₈H₃₈N₆O₁₁S |
| Molecular Weight | 666.7 g/mol |
| Strength | 50mg per tablet |
| Storage | Room temperature, dry environment, protect from light |
These HEMI PHARMA tablets provide standardised potency for research applications requiring precise compound delivery. Storage under controlled conditions ensures compound stability throughout experimental timeframes. Teams studying selective androgen receptor modulators often incorporate PDE5 inhibitors as positive controls in vascular function assays, while peptide researchers may examine synergistic effects with vasoactive peptides in endothelial cell culture studies.
Research Compliance Statement
This sildenafil citrate product is supplied exclusively for in-vitro research purposes and laboratory investigations. Not approved for human consumption, clinical use, or therapeutic applications. Researchers must ensure compliance with institutional guidelines and relevant regulations governing research chemical handling. Proper laboratory safety protocols and waste disposal procedures should be followed when working with this compound in experimental settings.
